2001 dodge grander caravan sport misfire cylender 1

first, disconnect the maf sensor to see if it will run better.
any codes?

Is the rattling sound coming from the exhaust? I'm wondering if perhaps you have a loose catalytic converter. P0300 (multiple cylinder misfires) and P0306 (cylinder #6 misfire detected) are probably the cause as to why the car is sluggish, shakes, runs rough and lacks power. Make sure to take a close look at your ignition system (spark plugs, ignition wires, coils...). A spray bottle filled with soapy water can help you find voltage leaks on the wires and coils. Just spray the wires and coils and look for arcing. Replace any component that arcs. Other causes can be fuel injectors, vacuum leaks...).

Hi Jason:
A Random/Multiple Cylinder Misfire Detected unfortunately doesn't tell you specifically which cylinder(s) is/are mis-firing, nor why.

A code Random/Multiple Cylinder Misfire Detected may mean that one or more of the following has happened:
Faulty spark plugs or wires
Faulty coil (pack)
Faulty oxygen sensor(s)
Faulty fuel injector(s)
Burned exhaust valve
Faulty catalytic converter(s)
Stuck/blocked EGR valve / passages
Faulty camshaft position sensor
Defective computer

Possible Solutions:
If there are no symptoms, the simplest thing to do is to reset the code and see if it comes back.

If there are symptoms such as the engine is stumbling or hesitating, check all wiring and connectors that lead to the cylinders (i.e. spark plugs). Depending on how long the ignition components have been in the car, it may be a good idea to replace them as part of your regular maintenance schedule. I would suggest spark plugs, spark plug wires, distributor cap, and rotor (if applicable). Otherwise, check the coils (a.k.a. coil packs). In some cases, the catalytic converter has gone bad. If you smell rotten eggs in the exhaust, your cat converter needs to be replaced. I've also heard in other cases the problems were faulty fuel injectors.

Random misfires that jump around from one cylinder to another (read: P030x codes) also will set a P0300 code. The underlying cause is often a lean fuel condition, which may be due to a vacuum leak in the intake manifold or unmetered air getting past the airflow sensor, or an EGR valve that is stuck open.

Hope this helps; also keep in mind that your feedback is important and I`ll appreciate your time and consideration if you leave some testimonial comment about this answer.

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had the same thing with my crown vic on the #8 cylinder. changed plugs and wires. still missing. wound up replacing the coil pack. you can check resistence of the coil between companion spark plug towers. ford marks each tower with 2 cylinder #'s. resisistence should be around 10-12 ohms

It could very well be a bad coil pack,or you have low compression in that cylinder.If the compression is good then go with the coil pack,if not you may need a head gasket or an intake manifold gasket.

I have a 2001 Dodge Grand caravan Sport i have a misfire in cylinder 2 i changed the spark plugs,wires,coil,map sensor,COMPUTER,had it checked for vacum leaks (nothing),fuel filter.Basically I have almost redone the whole van and i still have the same problem. Can anyone suggest what else i could try! please

A P0306 code means that the the ECM has detected that one of the engine's cylinders is not firing properly. In this case it's cylinder #6.

A code P0306 may mean that one or more of the following has happened:
Faulty spark plug or wire, Faulty coil (pack), Faulty fuel injector, Burned exhaust Valve, Poor compression, and Defective computer. 

Check all wiring and connectors that lead to the cylinders (i.e. spark plugs). Depending on how long the ignition components have been in the Caravan, it may be a good idea to replace them as part of your regular maintenance schedule. I would suggest spark plugs, spark plug wires, distributor cap, and rotor (if applicable). Otherwise, check the coils (a.k.a. coil packs). The number six cylinder is the one towards the radiator and drivers side. If you are going to change all the plugs and wire keep me posted, be glad to help. Good luck and hope this helps, P0300 just means multi miss fire. 

I HAVE A 96 DODGE CARAVAN WITH A 3.8L ENGINE..I HAD SIMILAR PROBLEM AND IT WAS THE UPPER INTAKE PLENUM GASKET HAD PIECE MISSING OUT OF IT..MISSING ON #5 CYLINDER AS WELL..GASKET WAS ONLY ABOUT 10 BUCKS AND I REPLACED IT IN ABOUT 30 MINUTES..TOOK ALL BOLTS OUT OF MANIFOLD AND JUST LIFTED IT UP HIGH ENOUGH TO GET OLD GASKET OUT..MIND YOU..I'M AN EXPERIENCED CHRYSLER TECH AND DO A LOT OF ENGINE WORK..SQUIRT SOME BRAKE CLEANER AROUND UPPER INTAKE AND SEE IF ENGINE SMOOTHES OUT..LET ME KNOW WHAT HAPPENS

did you check to make sure the plug wires are not carbon tracked. will look like light burn marks, or like someone drew on them with a pencil. if their ok might want to do a compression test on the motor just in case you've got a bad cylinder

YOu should be able to tell if coolant leaks caused the coil pack to fail. I believe it is 2 issues.