1988 GMC P/U windows and door locks don't work,

Fuses? Frayed wiring?

the leakage inside the door lock maybe damage or deslocate try to check

Check for a faulty power window relay.

The most likely culprit is your driver's door control module... it's built into the driver's window switches. Double-check all your fuses before replacing any parts.

Before you replace anything, inspect the connector pins in both the driver's door switch and the passenger door switch. If you don't find any problem with these connector pins, replace the driver's door control switch.

check for for broken wires where door hinges are at. pull back rubber boot and check them.

For Doors not getting open with remote or key problem,there are help links provided below.Click the link below to go through its procedure and troubleshoot the problem:----
drivers side front door will not open from inside or outside?

http://technoanswers.blogspot.com/2012/01/ford-f-350-crew-cab-drivers-side-front.html

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Car door will not close?
http://howtobyme.blogspot.com/2011/11/car-door-will-not-close.html

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All power door locks not working ?
http://howtobyme.blogspot.com/2011/11/all-power-door-locks-not-working-on_14.html

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Repairing car Door lock Actuator?
http://howtobyme.blogspot.com/2011/11/repairing-car-door-lock-actuator.html
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How to Access car door panel?
http://howtobyme.blogspot.com/2011/11/how-to-access-car-door-panel.html

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Vehicle door panel components?

http://howtobyme.blogspot.com/2011/11/vehicle-door-panel-components.html

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Truck Door will not close?

http://schematicsdiagram.blogspot.com/2011/12/ford-truck-door-will-not-close.html

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Where is Cars Door control Module located?

http://schematicsdiagram.blogspot.com/2011/12/where-is-cars-door-control-module.html

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Power door locks not working?

http://schematicsdiagram.blogspot.com/2011/12/power-door-locks-not-working.html

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Door ajar light stays on?

http://technoanswers.blogspot.com/2012/01/door-ajar-light-stays-on.html

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Door locks not working?

http://technoanswers.blogspot.com/2012/01/door-locks-not-working-on-ford-explorer.html

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Front Door dis-assembly diagram?

http://repairhelpcenter.blogspot.in/2012/02/front-door-dis-assembly-diagram-for.html

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Rear Door dis-assembly diagram?

http://repairhelpcenter.blogspot.in/2012/02/rear-door-dis-assembly-diagram-for.html

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How to test Power door locks?

http://repairhelpcenter.blogspot.in/2012/02/how-to-test-power-door-locks.html

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Doors will not open with Remote?

http://schematicsdiagram.blogspot.in/2012/02/lexus-doors-will-not-open-with-remote.html

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How to replace Door Hatch ?
http://repairhelpcenter.blogspot.com/2011/11/how-to-replace-hatch-on-acura-integra.html

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How to remove Doors?

http://repairhelpcenter.blogspot.com/2011/11/how-to-remove-doors-on-acura-integra.html

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How to Replace Doors?
http://repairhelpcenter.blogspot.com/2011/11/how-to-replace-doors-on-audi-a4-and-vw.html

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Remote will not unlock Rear door?
http://schematicsdiagram.blogspot.com/2011/12/remote-will-not-unlock-rear-door-on-gmc.html

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Door locks or windows not working on car?
http://schematicsdiagram.blogspot.com/2011/07/door-locks-or-windows-not-working-on.html

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This will help.

Thanks.

I assume you are talking about the controller on the driver's door. The Driver's Door Module is likely defective. For troubleshooting purposes, you can swap in the passenger side module to verify.

I have a similar problem. The remote sometimes opens all doors, and other times it will only open the 2 rear doors. Once inside the vehicle, the driver side window controls intermittently operates all windows and doors. It has no effect on the 2 rear doors, as the window controls still work. This behavior happens intermittently while driving the vehicle.

make sure than you have not split any fluids on the passenger front door most of the times is where the module to control the windows and doors is located, try by unpluging the batterie and the after a minute plug it back and see what happend but if any of your ft doors have been split with liquid or rain has gone inside then most likelly the module got moisture and not working