Transmission interchange will a 4x4 chevy blazer 4l60e transmission interchange with a two wheeldrive 4l60e

Yes, but the steps involved in switching the 4wd output shaft, over to the 2wd output shaft are very involved. Thats assuming that the bellhousings are identical. (detachable bellhousing) That you do not need a 30 spline input shaft for your torque converter (96+ blazer input shaft splines are all 28 splines, however you may need a 30 spline in order for the correct torque converter to fit your 2wd vehicle.) You will need to know what 2wd output shaft you need, there are quite a few variations. Then you would need to take the pan off, pull the shift soleniod blocking access to the lockup soleniod, remove the lockup soleniod, remove the pump bolts, pull the pump, unhook the 2nd/4th, band remove the reverse drum - 3/4 drum (by pulling the input shaft twards you) then remove the yellow snap ring holding the output shaft in place. Now the output shaft is able to be removed and switched. Re instalation of the drums/pump is tricky as well, as all the clutches need lined back up to slide back onto there corasponding splines. Long story short, it would be alot more trouble than its worth. : )