2003 mercedes c240 drivers door wont lock with fob but unlocks other locks lock and unlock has new latch/lock assembly

No ,it's not the actuators . It could be the BCM - body control module.

How to test computer controlled door locks
Each door lock switch is wired to the body control module (BCM) through a separate door lock/unlock signal circuit. While these circuits are separated between the BCM and respective door lock switch, they are connected into a single circuit within the BCM. The BCM supplies voltage through the door lock/unlock signal circuits to each door lock switch. When either door lock switch is operated, this supply voltage is pulled to ground, providing the BCM with the required lock or unlock signal. In order for the BCM to distinguish between a lock and unlock signal, the lock switch contains two separate paths for this voltage to flow to the same body ground. When the switch is operated to the unlock position, the supply voltage flows to ground through a 1.5 K ohm resistor. When the switch is operated to the lock position, the supply voltage flows to ground through a different part of the switch circuit, which has no resistor. The BCM then interprets the flow of voltage as a lock or unlock request and powers the door lock actuators to the appropriate lock or unlock position.
The BCM powers the reversible door latch assemblies by providing battery positive voltage and ground to the appropriate lock and unlock control circuits of the door latch assemblies. The Lock control circuits of the driver and passenger door latch assemblies are all connected together; however, the Unlock control circuits are connected in a slightly different way. While the unlock control circuits for the passenger door latch assemblies are connected together, the door latch assembly has a separate unlock control circuit. The system is designed this way so that the keyless entry transmitter may be used to unlock only the driver door. Despite this difference, all of the lock actuators perform much the same way. When the door latch assemblies are not active, all actuator Lock and Unlock control circuits are at ground potential within the BCM. Transitioning of the lock actuators to the lock or unlocked position depends upon which control circuits receive voltage and which control circuits receive ground.

replace the latch or chek latch cables or link from lock cyldr

Could be your driver door lock mechanism that is going bad , since the other door are working, it cannot be the fob. I would try to change the driver side door latch mechanism.

TRY A NEW BATT IN THE KEY FOB.

They are very common for the door latch actuator assembly. Usually it starts when one particular door stops locking or unlocking. The lock rod will only partially go up or down, then gradually stop all together. The actuator used to be a separate component, however now it is integrated into the entire latch assembly. It most likely is the problem and will need replacing. If its just an issue that your key fob doesn't work anymore try replacing the battery in the fob. Then hold the lock and unlock buttons for 7 - 10 seconds to re-synchronize the transmitter.

Hi, if all of the locks on your Mercedes fail to open (or close) first check your key fob to make certain that its battery is working. Replace the worn out battery, if necessary. If key fob is working, you may have a faulty key fob, which can be repaired or replaced by taking it to your dealer.
If just one lock won't open on your Mercedes, then the problem may rest with broken wiring, a bad solenoid, or perhaps with a blown fuse. Check your fuse box first to determine if a blown fuse is keeping the lock from working. If so, replace the fuse.
You likely have a shorted door lock actuator, which you can replace with a new unit for the lock that is not working. If a door unlocks, but will not lock again, then replace the door switch.

Besides there is not OBD II 888 code, i have never heard or seen it before...

when inside the vehicle and you driveaway the door lock and then probably with your issue unlock automatically.
One of the front door latches/actuator assembly has failed.
You need to look at both the front locks when locking the vehicle (where the handle is) look and see which ones do not lock.
It will be either the drivers front or the passenger front.
Once determined, that latch assy will need replacing

I have a 2001 C240 with the same issue. I removed the positive battery cable from the battery and kept it off for 30 seconds then replaced it. Everything was reset and the key worked.

if the passenger side works with the fob and the power button and not the diver it is def the driver door lock actuator.

If you have tried the inside, and outside door handle, and it does not open you need a new door latch assembly.