Key lock on drivers door won't unlock the door

It sounds like the key sensor in the drivers door is malfunctioning, the drivers door is the only door that can enable/disable the alarm, if you try to unlock any of the others it will trigger the alarm.

Sometimes with my Kia I have to (without opening the door), cycle lock and unlock several times before the alarm is disarmed.

Have you tried this is succession, with all the doors locked:-

put the key in the drivers door, turn to lock and then to unlock, the alarm should disarm.

Also, if any of the door locks are jammed, the alarm will still activate when you try to unlock the drivers door.

If that fails and the alarm still activates, then it's a problem with the key sensor in the door.

This is usually caused by broken plastic parts in the lock system. The best would be to verify and lub all locks and check out the elecrical.
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kess v2

1) Key turns but dose not unlock door. This means that the rod that goes to the back of the lock has came off. This also means that is the reason door is not unlocking with the remote as it pops the lock rod inside the door which pushes the lock open.
2) Key does not turn lock at all but works passengers side door. This means that the locks has been changed in the door, but that doesn't sound like the problem as you say the remote doesn't open the drivers side door so more than likely the rod has came off the back of the lock

Try spraying some liquid graphite into the door lock and keep trying to work the key to turn.

put key in drivers door, turn to lock and then to unlock and try to start, if it still does not start use a different key.

Troubleshooting is required to inspect few parts.It can be issue with ignition switch.Its not getting off.Or issue with sensor or wiring.Or its faulty lock itself.Click the link below and follow the troubleshooting:----Driver Door will not lock or unlock with Key or Remote? http://whatisbyme.blogspot.in/2012/05/1998-toyota-landcruiser-driver-door.html
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Driver side door will not lock or unlock with Remote? http://technoanswers.blogspot.in/2012/04/2009-toyota-tundra-driver-side-door.html
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Central locking not working ? http://schematicsdiagram.blogspot.in/2012/03/this-is-how-system-operates.html

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Remote will not unlock Rear door ?
http://schematicsdiagram.blogspot.com/2011/12/remote-will-not-unlock-rear-door-on-gmc.html

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Repairing car Door lock Actuator?
http://howtobyme.blogspot.com/2011/11/repairing-car-door-lock-actuator.html

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How to Access car door panel?
http://howtobyme.blogspot.com/2011/11/how-to-access-car-door-panel.html

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Vehicle door panel components?
http://howtobyme.blogspot.com/2011/11/vehicle-door-panel-components.html

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This will help.
Thanks.

this is a problem that can appear after your car battery died, cause the car didn't reset propely, so taking the battery out and putting it back in or letting your car die again would do the trick. I tried a lot of reprogramming procedured for my remote key, none of them worked, what did the trick though was simply unlocking the doors via the all door unlock button on the passenger side door, so simple.

Your door lock actuator have issues

change battery in remote

I have an A4 and did this to re-program my key:

1. used the key to start the car...then turned it off
2. put the key in the driver door (door closed)
3. pressed the lock button on the key fob once
4. turned the key to lock the door.

This is basically the steps in the owners manual, but the car must be started with the key first, and the key must be in the door lock before pressing the lock button.