What would cause an engine to cut off while driving?

SOURCE: 1994 chev. S10 4.3

There is a sensor device, on the right side of the engine block near the front, for the oil pressure that has two parts to it. It is used to control the oil pressure guage on the dash as well as having a switch which has wiring going to the Electronic Control Module, and this ECM input has a software time-out safety feature. After the engine is started, if the indicated oil pressure goes too low or is lost, the voltage to the fuel pump is shut off. This is desired in the case of a crash. This event will cause the engine to quit. On my manual transmission vehicle the ECM will reset if the ignition is turned off for a couple of seconds. It sounds like this oil pressure (aka sending unit) sensor is not working properly, causing the fuel pump power to be removed.....(probably intermittently). About $20 and a few minutes to change if you can get your hands down in there.

SOURCE: on my blazer s10 4

first make sure all is well take that 10 amp fuse out and try a 20 amp then a 25 amp fuse then let me know and ill help you furthur diagnose it.

SOURCE: Chevy tahoe shuts off when driving

replace fuel pump relay. check all fuses to ignition and pcm .make sure they are not loose. check coil wires make sure they not loose.look at battery if you have the ac delco seal battery make sure green eye still there .if its black have battery check out.

SOURCE: 1987 k5 blazer dies during driving

Make sure your battery is secured by a good battery hold-down system...if the battery shifts in the tray and the positive terminal touches the fender, the dead short will immediately kill the vehicle.
Also, take the alternator to a parts store and have it tested if your battery is held down firmly. The whining noise can be bad alternator bearings. On a vehicle of this vintage, this is a possibility for the noise. It is furthermore possible that the alternator has died electrically, and during a lengthy drive, the vehicle's own electrical consumption will drain the battery and the vehicle will die en route.
When you jump it off, it gets enough charge from the donor vehicle to drive, but if the alternator is dead, it can't keep the vehicle supplied with enough energy to operate.

SOURCE: cuts out under load. 78 chevy pickup. 1/2 ton

Some things you can check. First, with the engine off, look down into the carburetor and quickly move the throttle. You should see a squirt of fuel. If not, the accelerator pump is bad. If that is OK, check the spark itself. It should bridge a half inch gap with no problem and should be healthy (have good "snap" and bluish color). If OK, check the two wires that run from the ignition module inside the distributor, down under the breaker plate.Often those wires can partially break or short to the housing...when the advance moves the plate it will cause a problem.
Only other thing I can think of is timing. That engine likes from 8 to 12 degrees advance (depends on fuel quality) if it's set wrong it can make it fall on it's face when you floor it. (bad chain can do that too).