Engine 1 fuse keeps blowing when you turn the key

Sounds as if you have a power shortage in the van. first establish what fuse keeps blowing this will help in narrowing down the short.once short is located check all connections ,wires,and plugs.

Engine 1 fuse powers the computer and some sensors. I had this same problem on a 98 chevy van 3500 and found the wire going to one of the oxygen sensors had shorted out on the heat shield. Inspect the wires going to all of the oxygen sensors. On this van one of the oxygen sensors on the driverside the wire was laying on the heat shield which eventually rubbed through the wire and shorted it out blowing the fuse. Your short could be on a different sensor but check all of the oxygen sensors because the wire runs so close to the sharp heat shield.