After installing a new oil pump does it have to be set to the crank on a 2006 chevy Silverado 4x4V8 6.0 vortex

No info generic answer vortex engines yes

The oil pump is driven off the cam gear on the bottom of the dist. The pump just needs to pump and hold the correct oil pressure for the engine. Hope this helps.

You need to prime it that is all.

Did you prime the oil pump? Pack it with vasoline? Crank the engine without starting it until oil pressure came up?

where the oil pressure sender unit is on the block install a "t" fitting . Place the electrical unit in one side and a brass fitting in the other . Run the copper line from the gauge through the firewall to the "T" piece and connect up (if you are using a plastic tube the do not waste your time as the plastic fails -cracks ,slips. or melts causing engine failure) Position the gauge and connect the copper line to the gauge . run engine and check for oil leaks.

remove the pump and the cover off the gears
fill the spaces of the gear teeth with Vaseline or clean grease
this is priming the pump so that a vacuum is created to suck up the oil
new pumps will not be primed
the grease /Vaseline will dissolve in the oil and will not cause any problems

yes near oil filter and did you change oil latly and didnt remove the old gasket of the filter sometime its sticks to the engine and you dont see it if not sure where the leak is wash engine good and run it for a few minutes to see exactly where leak is

High milage? Try engine cleaner, run for couple hundred miles and then use an additive like Restore. If it's just dirt this may help. Make sure you are using the correct viscosity oil for winter temps. If it's from wear only parts replacement will fix it.

There is one for the computer and one for the gauge. One is on the intake and one screwed into the front water neck on the intake or on the water pump.