How do I unlock my nook when the screen wont respond to touch when you swipe to unlock

Here are two things to try:
I- Using the Power button:
1 Press and hold the Power button for at least 4 seconds.
2 Swipe-down the shutdown confirmation screen to the bottom
edge of the display to turn off the tablet.
Using Charms:
1 Swipe-in from the right edge of the display to access Charms.
2 Touch Settings
Turning Off the Screen
Using the Power button:
Press the Power button to turn off the screen.
Using Charms:
1 Swipe-in from the right edge of the display to access Charms.
2 Touch Settings
NOTE: If your tablet is in a standby state (tablet is on, but screen is off), press the Power button or Windows button once to turn on the screen.
12
'
Setting Up Your Tablet
? Power
? Shut down to turn off the tablet.

II- Unplug the battery, wait 30 seconds, then install the battery again.

For some books, downloaded from your PC, the only way to delete them is to attach the Nook Simple Touch to your PC and open the Nook Simple Touch on the PC. (For a PC, open the computer icon and look for the Nook icon and click on that.) From your PC you can delete files from the Nook Simple Touch or move them off the Nook Simple Touch to your PC.
IF you have a MAC or if my advice doesn't work, you should contact the Nook support. It is at the Nook website. Click on Nook and look for Nook support.

I find this happens to me sometimes as well.
The screens are capacitive touch sensitive which means it responds to the small amount of electricity on your skin. If your fingers are damp, from sweat, high humidity, then the capacitance will not reach a level for the screen to react to.
Keep your fingers dry and keep the screen very clean and free of oils.

Press the Power button longer until your tablet shuts down. If you can restart it, find a cache cleaner software to clear the cache for more space. Sometimes, the cache takes up nearly all the available space from the tablet's ROM. This slows down the tablet considerably and also causes malfunctioning of the OS.

Best bet is to reset the Nabi...hold the power button in for about 8 seconds. The tablet will shut down and restart. Unless you've dropped the Nabi (hard, my kids drop it often) it should restart and behave.

You may have a damaged wire connecting the screen to the phones mother board

Simple touch glowlight 2012 model. My touch screen wouldn't work. I had full battery. I couldn't power down using the power down button, I had to force it to shut down. I couldn't slide the unlock nor could I turn pages with screen. I only could turn pages with buttons on side. After much research I found that it just needed a simple cleaning. I used a vacuum to gently suck out dust in the crevice of the screen. Or you can use a canister of air to blow the dust out. Do this at an angle so that you don't blow it deeper into the crevice. Also, Use a cloth misted with H2O (almost dry) to wipe the screen from edge to edge. These screens use sensors that are from the side of the screen.. Debri will block the sensors. Mine works great. Too bad I already purchased another one after I found the solution.

Its a comman hardware problem, not Software.
Take it to the authorized service center,
They will replace it.

You'll have to factory reset it by turning it off and holding the home button and power button at the same time I know because I got into my hidden setting and accidently turned it on myself

TRY a hard reset on the Nook if that doesn't work i know of this fantastic site BNTPrice.com that sells them for cheap. i hope this works for you

1. Press the "n" button to display the quick nav bar.
   

2. In the quick nav bar, tap the Settings icon.
   

3. In the Device Settings section, tap Device Info.
   

4. Tap Erase & Deregister Device.
   

5. Stop. Think. Think again.
   

6. If you really, really want to do this, go to Step 7. If not, tap the Back button.
   

7. Tap the Erase & Deregister Device button.