He had an infarction in his right thigh. Similar to a clot that causes a stroke if it is in the brain, a heart attack if it is in the heart and an embolism if it is in the lung, an infarction in his leg blocked the flow of blood. House explains this in the "Pilot." It is further explained in "Three Stories" that his condition went misdiagnosed for three days causing severe nerve damage and muscle death. They wanted to amputate his leg but he opposed it. The surgery that tried to restore blood circulation and removal of dead muscle tissue left his leg permanently impaired and in chronic pain
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