The loop and the manual tone store functionality !
Usually the loop in is used with an EXTERNAL effects module where the audio signal is "looped" out through the external effect module and then back to the power amp to drive the speaker in the cabinet. The LOOP IN jack would receive signal from the EFFECTS module OUT jack.
The source to go TO the effects module INPUT may come from a jack such as preamp out, or sometimes the same loop jack if it usess the TRS (Tip-Ring-Sleeve) connection method.
If you do not have an external effects module, all this is a moot point in your case.
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