Using Harmony 650 remote by Logitech. Works fine for TV, DVD and partially works for Roku (Netscape streaming, etc.)...But when using the Roku, the new remote does not control the volume nor does the Mute button work. Any ideas.

SOURCE: Harmony 880 Logitech tv remote - won't change channels on direct tv

If you have an infrared remote and your Direct Tv remote is using an RF signal then you need to call Direct Tv and they will help you program your DVR to the remote.

SOURCE: I like to program in my Roku box for streaming

You can download the software to program your remote from the site below.

When adding devices, the Roku is listed under Satellite Receivers. I have a Harmony 880 and recently programmed it to add a Roku.

http://www.logitech.com/index.cfm/440/2984&hub=1&cl=us,en?osid=13

SOURCE: I need instruction to dissasembly the logitech harmony 550

It´s very simple to disassemby it, you need to force with a little screwdriver as shown in these images.

SOURCE: logitech harmony 550 volume problem

I would call or email in to logitech and suggest that they copy some of the learned commands for your bose system into your harmony remote account.

The commands they add are learned from other customers and they will only copy the best ones. Give it a shot.